Dichloromethane → HCID 20689421、化合物
反応式
[Br:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C(Cl)Cl.C(O)(C(F)(F)F)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1参加物
4
実験手順
To a solution of tert-butyl 4-(4-bromobenzyl)piperidine-1-carboxylate (780 mg, 2.2 mmol) in CH2Cl2 (15 mmol), was added TFA (0.5 mL) and the mixture was stirred at rt for 1 h. The solvent was removed in vacuo and the residue dissolved into CH2Cl2 (50 mL), washed with NaOH (0.1M, 10 mL), brine (10 mL), dried over MgSO4 and concentrated to dryness to give the title compound as a beige solid (520 mg, 93%).
後処理
- customThe solvent was removed in vacuo
- dissolutionthe residue dissolved into CH2Cl2 (50 mL)
- washwashed with NaOH (0.1M, 10 mL), brine (10 mL)
- dry with materialdried over MgSO4
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-04b4e5e72c924f5eb0f20f37ef0699f1
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999968B2
反応ノート
読み込み中…