Methanol → Methyl 4-(1-aminocyclopropyl)benzoate
反応式
[NH2:1][C:2]1([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)[CH2:4][CH2:3]1.CO.[CH3:16][Si](C=[N+]=[N-])(C)C.CCCCCC>C1COCC1>[NH2:1][C:2]1([C:5]2[CH:13]=[CH:12][C:8]([C:9]([O:11][CH3:16])=[O:10])=[CH:7][CH:6]=2)[CH2:4][CH2:3]1参加物
6
実験手順
4-(1-aminocyclopropyl)benzoic acid (1.75 g, 0.00988 mol) was stirred in THF (20 mL) and Methanol (10 mL) over ice/water bath. 2.00 M of trimethylsilyldiazomethane in hexane (9.9 mL, 0.020 mol) was added and the mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated down to viscous oil which solidified upon standing to give a crystalline solid. Crude material was dried on high vacuum line for 12 hours to give methyl 4-(1-aminocyclopropyl)benzoate (1.65 g, 87%) as pale brown solid.
後処理
- concentrationThe reaction mixture was concentrated down to viscous oil which
- customto give a crystalline solid
- customCrude material was dried on high vacuum line for 12 hours
出典と根拠
- ORDレコード
- ord-7407d88d941c48b0880db251dbbbc6b4
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09000024B2
反応ノート
読み込み中…