Nitric Acid → N-(2-nitro-4-phenoxy-phenyl)acetamide

HRID 1466470ノート

反応式

HRID 1466470 の反応式
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:17])[CH3:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:18]([O-])([OH:20])=[O:19]>>[N+:18]([C:10]1[CH:9]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:13]=[CH:12][C:11]=1[NH:14][C:15](=[O:17])[CH3:16])([O-:20])=[O:19]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 80579N-(4-Phenoxyphenyl)acetamide

生成物 1

HCID 3828525N-(2-nitro-4-phenoxy-phenyl)acetamide

反応条件

温度
-15 °C

実験手順

N-(4-phenoxy-phenyl)-acetamide (1.00 g, 4.03 mmol) prepared in Step A was dissolved in fuming nitric acid (2 mL), and the mixture was stirred for 2 h at −15° C. After completion of the reaction, the reaction mixture was poured into 100 mL of ice water, which was then extracted with ethyl acetate. The extracted organic solution was dried over anhydrous magnesium sulfate, the solvent was removed under reduced pressure, and the residue was purified by column chromatography to give the title compound (0.67 g, 2.33 mmol).

後処理

  1. customAfter completion of the reaction
  2. extractionwas then extracted with ethyl acetate
  3. dry with materialThe extracted organic solution was dried over anhydrous magnesium sulfate
  4. customthe solvent was removed under reduced pressure
  5. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-4e2860ca5f2b45109f1b46d7973998c3
出典データセット
uspto-grants-2015_04
特許番号
US09000028B2

反応ノート

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