Chloroacetone → HCID 66764943、化合物

HRID 1466816ノート

反応式

HRID 1466816 の反応式
[CH2:1]([O:3][C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([SH:13])[CH:6]=1)[CH3:2].C(N(CC)CC)C.Cl[CH2:23][C:24](=[O:26])[CH3:25].CCOC(C)=O>C1COCC1>[CH2:1]([O:3][C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13][CH2:23][C:24](=[O:26])[CH3:25])[CH:6]=1)[CH3:2]

参加物

6

反応物 4

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 66764668HCID 66764668、化合物

生成物 1

HCID 66764943HCID 66764943、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3-Mercapto-4-methoxy-benzoic acid ethyl ester (1.29 g, 6.08 mmol) and triethylamine (2.12 mL, 15.19 mmol) were dissolved in THF (20 mL) at 0° C. Chloroacetone (0.58 mL, 7.29 mmol) was then added and the reaction stirred at room temperature for 30 minutes. It was then allowed to slowly warm to room temperature and stirred an additional 30 minutes. Standard aqueous workup followed by silica gel chromatography (0-70% EtOAc in hexanes) gave the title compound.

後処理

  1. temperatureto slowly warm to room temperature
  2. stirringstirred an additional 30 minutes

出典と根拠

ORDレコード
ord-3720f8e87e0343edb07455a2d4f8fa81
出典データセット
uspto-grants-2015_04
特許番号
US09000025B2

反応ノート

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