3-Fluoro-5-(4-methoxy-benzylsulfanyl)-benzoic acid ethyl ester → 3-Fluoro-5-mercapto-benzoic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([S:11]CC2C=CC(OC)=CC=2)[CH:8]=[C:7]([F:21])[CH:6]=1)[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([SH:11])[CH:8]=[C:7]([F:21])[CH:6]=1)[CH3:2]参加物
3
実験手順
3-Fluoro-5-(4-methoxy-benzylsulfanyl)-benzoic acid ethyl ester (7.24 g, 22.5 mmol)was stirred in TFA (10 mL) at 70° C. for overnight. The resulting mixture was cooled to room temperature and subjected to standard aqueous workup. The crude residue was purified on silica gel (0-30% EtOAc in hexanes) to afford the title compound.
後処理
- customThe crude residue was purified on silica gel (0-30% EtOAc in hexanes)
出典と根拠
- ORDレコード
- ord-fb6a0a8e1ddf406087c3bb1518feae61
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09000025B2
反応ノート
読み込み中…