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HRID 1466930作成日：2026年10月27日
3-(6-Bromo-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester → 3-(6-Cyano-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester
https://huagongshe.com/reaction/1466930
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-(6-Bromo-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester | HCID 66765362 | — |
| 反応物 | HCID 178418546 | HCID 178418546 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 3-(6-Cyano-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester | HCID 66765015 | — |
反応手順
3-(6-Bromo-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester (0.19 g, 0.5 mmol) and copper(I) cyanide (0.090 g, 1.0 mmol) were combined in DMSO (10 mL) in a sealed reaction vessel and stirred at 130° C. for overnight. The resulting mixture was cooled to room temperature, and subjected to standard aqueous workup. The crude residue was purified by silica gel chromatography (10-100% EtOAc in hexanes) to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09000025B2 |
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| 出典データセット | uspto-grants-2015_04 |
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| ORD ID | ord-db0ee61546dd4ff39c5e898034005119 |
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| 出典メモ | uspto-grants-2015_04 |
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