Potassium Carbonate → HCID 178468952、化合物

反応式

[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17](Cl)=[CH:18][CH:19]=3)[N:14]([C:23]#[N:24])[C:13]=2[CH3:25])[CH:6]=1)[CH3:2].[ClH:27].[NH2:28][OH:29].C(=O)([O-])[O-].[K+].[K+]>CCO>[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:27])=[CH:18][CH:19]=3)[N:14]([C:23](=[NH:24])[NH:28][OH:29])[C:13]=2[CH3:25])[CH:6]=1)[CH3:2]

参加物

実験手順

3-(6-Chloro-1-cyano-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester (0.45 g, 1.15 mmol), hydroxylamine hydrochloride (0.40 g, 5.79 mmol), and potassium carbonate (0.80 g, 5.79 mmol) were combined in absolute EtOH (4 mL) and stirred at reflux for overnight. The heterogeneous mixture was then filtered, and the solids were washed with hot absolute EtOH (2×10 mL). The resulting filtrate was concentrated to dryness under reduced pressure to afford the title compound.