Trifluoroacetic acid → N-(4-(3-fluorophenyl)piperidin-3-yl)-3-(pyridin-4-yl)-1H-indazole-5-carboxamide
反応式
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:10]=[C:11]([CH:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH:16]2[NH:28][C:29]([C:31]2[CH:32]=[C:33]3[C:37](=[CH:38][CH:39]=2)[N:36](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:35]=[C:34]3[C:59]2[CH:64]=[CH:63][N:62]=[CH:61][CH:60]=2)=[O:30])[CH:12]=[CH:13][CH:14]=1>C([SiH](CC)CC)C>[F:8][C:9]1[CH:10]=[C:11]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH:16]2[NH:28][C:29]([C:31]2[CH:32]=[C:33]3[C:37](=[CH:38][CH:39]=2)[NH:36][N:35]=[C:34]3[C:59]2[CH:60]=[CH:61][N:62]=[CH:63][CH:64]=2)=[O:30])[CH:12]=[CH:13][CH:14]=1参加物
4
実験手順
Trifluoroacetic acid (1 mL) was added to tert-butyl 4-(3-fluorophenyl)-3-(3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate (0.105 mmol). The reaction was stirred at room temperature for 30 minutes. Triethylsilane (1 drop) was added to the reaction and stirred for an additional 5 minutes. The reaction was concentrated in vacuo and purified using prep LC/MS.