N-[(4-Fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl ester → N-[(3-Amino-4-fluorophenyl)-carbamoyl]glycine, ethyl ester

HRID 1468

反応式

HRID 1468 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:10])=[CH:4][C:3]=1[N+:18]([O-])=O.[H][H]>[Pt].C(OCC)(=O)C>[NH2:18][C:3]1[CH:4]=[C:5]([NH:8][C:9]([NH:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:10])[CH:6]=[CH:7][C:2]=1[F:1]

参加物

5

反応物 2

HCID 85708209N-[(4-Fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 85708212N-[(3-Amino-4-fluorophenyl)-carbamoyl]glycine, ethyl ester収率 60.8%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of N-[(4-fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl ester (8 g, 0.029 mol) and 5% platinum on activated carbon (0.5 g) in ethyl acetate is hydrogenated at 50 psi until hydrogen uptake is complete. The reaction mixture is then filtered and cooled in an ice-bath until a solid forms. The solid is collected by filtration and air-dried to give the title product as a white solid (4.5 g, mp 152°-153° C.).

後処理

  1. filtrationThe reaction mixture is then filtered
  2. temperaturecooled in an ice-bath until a solid forms
  3. filtrationThe solid is collected by filtration
  4. customair-dried

出典と根拠

ORDレコード
ord-c5aff79410674f0180c8c0f0b265e45b
出典データセット
uspto-grants-1998_03
特許番号
US05726126

関連ノート

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