2-(4-Chloro-benzylidene)-3-methyl-succinic acid → 6-Chloro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid

HRID 1468333

反応式

HRID 1468333 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH:6]=[C:7]([CH:11]([CH3:15])[C:12]([OH:14])=O)[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>FC(F)(F)S(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:16][CH:17]=1)[CH:6]=[C:7]([C:8]([OH:10])=[O:9])[C:11]([CH3:15])=[C:12]2[OH:14]

参加物

3

反応物 1

HCID 673042002-(4-Chloro-benzylidene)-3-methyl-succinic acid

生成物 1

HCID 593265616-Chloro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid収率 98%

試薬・触媒・溶媒 1

HCID 62406Trifluoromethanesulfonic acid溶媒

実験手順

To a flask containing trifluoromethanesulfonic acid (40 mL), 2-(4-chloro-benzylidene)-3-methyl-succinic acid (14.0 g, 55 mmol) was added in portions. After being stirred at room temperature for 18 hours, the resulting mixture was poured onto ice-water, and stirred for 15 minutes. The formed precipitate was collected by filtration, and dissolved in ethyl acetate (150 mL). The solution was dried over sodium sulfate, and concentrated in vacuo. The residue was precipitated from ethyl acetate/petroleum ether (1:10) to afford 6-chloro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid (12.7 g, 98%) as a pink solid.

後処理

  1. additionwas added in portions
  2. additionthe resulting mixture was poured onto ice-water
  3. stirringstirred for 15 minutes
  4. filtrationThe formed precipitate was collected by filtration
  5. dissolutiondissolved in ethyl acetate (150 mL)
  6. dry with materialThe solution was dried over sodium sulfate
  7. concentrationconcentrated in vacuo
  8. customThe residue was precipitated from ethyl acetate/petroleum ether (1:10)

出典と根拠

ORDレコード
ord-a62b8f5ea0af4e3fb833fd019ee4e957
出典データセット
uspto-grants-2015_04
特許番号
US09000044B2

関連ノート

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