Ethanolamine → HCID 18706827、化合物
反応式
Cl[C:2]1[C:7]([NH2:8])=[C:6]([Cl:9])[N:5]=[C:4]([NH2:10])[N:3]=1.[CH2:11]([CH2:13][NH2:14])[OH:12]>C(O)C>[NH2:10][C:4]1[N:3]=[C:2]([NH:14][CH2:13][CH2:11][OH:12])[C:7]([NH2:8])=[C:6]([Cl:9])[N:5]=1参加物
4
反応条件
- 温度
- 105 °C
実験手順
A mixture of 4,6-dichloropyrimidine-2,5-diamine (28 g, 156 mmol), ethanolamine (18 ml, 312 mmol) and ethanol (250 ml) were heated at 100-110° C. for 16 hours. The mixture was cooled and solvent was removed. To the residue methanol (100 ml) was added and stirred for 20 minutes. The solid was filtered off to obtain 2-[(2,5-diamino-6-chloro-pyrimidin-4-yl)amino]ethanol (22.0 g, 70%).
後処理
- temperatureThe mixture was cooled
- customsolvent was removed
- additionTo the residue methanol (100 ml) was added
- filtrationThe solid was filtered off
出典と根拠
- ORDレコード
- ord-91f813d2a30a41c88ff9cc054e6507e6
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006177B2
反応ノート
読み込み中…