Hydrazine hydrate (1:1) → HCID 66824634、化合物
反応式
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:15])[C:7](=[O:14])[N:8]2[CH2:11][CH2:12][OH:13])=[C:4](Cl)[N:3]=1.O.[NH2:18][NH2:19]>C(O)C>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:15])[C:7](=[O:14])[N:8]2[CH2:11][CH2:12][OH:13])=[C:4]([NH:18][NH2:19])[N:3]=1参加物
4
反応条件
- 温度
- 105 °C
実験手順
A mixture of 2-amino-6-chloro-9-(2-hydroxyethyl)-7-methyl-purin-8-one obtained in step 3 (8 g, 32.9 mmol), Hydrazine hydrate (16 ml, 32.9 mmol) and ethanol (300 ml) were heated at 100-110° C. for 16 hours. The reaction mixture was concentrated and solid obtained was filtered off and dried to obtain 2-amino-6-hydrazino-9-(2-hydroxyethyl)-7-methyl-purin-8-one (7 g, 89%) as an off white solid.
後処理
- concentrationThe reaction mixture was concentrated
- customsolid obtained
- filtrationwas filtered off
- customdried
出典と根拠
- ORDレコード
- ord-217646fb081040968f451eef9125ef17
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006177B2
反応ノート
読み込み中…