Sodium Hydroxide → 4-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol

HRID 1469316

反応式

HRID 1469316 の反応式
Cl.Cl.[NH2:3][C:4]1[C:13]2[N:14]=[C:15]([CH2:25][CH3:26])[N:16]([CH2:17][C:18]3([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1.[OH-].[Na+]>>[NH2:3][C:4]1[C:13]2[N:14]=[C:15]([CH2:25][CH3:26])[N:16]([CH2:17][C:18]3([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 575155314-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol dihydrochloride

生成物 1

HCID 575155304-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol収率 93.3%

実験手順

A mixture of 4-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol dihydrochloride (0.80 g) and 1N sodium hydroxide (8 mL) was sonicated for 2 minutes. A solid was isolated by filtration, washed with water, and dried. This procedure was repeated and the material was dried under high vacuum at 120° C. to provide 0.61 g of 4-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol as a tan powder, mp 232.0-233.0° C. Anal. Calcd for C17H22N6O C, 62.56; H, 6.79; N, 25.75; Found: C, 62.43; H, 7.04; N, 25.78.

後処理

  1. customwas sonicated for 2 minutes
  2. customA solid was isolated by filtration
  3. washwashed with water
  4. customdried
  5. customthe material was dried under high vacuum at 120° C.

出典と根拠

ORDレコード
ord-9b593541b3734c6abdc75fced37bc246
出典データセット
uspto-grants-2015_04
特許番号
US09006264B2

関連ノート

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