Hydrochloric Acid → 4-(2-Methyl-benzothiazol-6-yl)-butyric acid
反応式
C[O:2][C:3](=[O:17])[CH2:4][CH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([CH3:14])[S:13][C:9]=2[CH:8]=1.[OH-].[Na+].Cl>CCO>[CH3:14][C:12]1[S:13][C:9]2[CH:8]=[C:7]([CH2:6][CH2:5][CH2:4][C:3]([OH:17])=[O:2])[CH:16]=[CH:15][C:10]=2[N:11]=1参加物
5
実験手順
Next, to a solution of 4-(2-methyl-benzothiazol-6-yl)-butyric acid methyl ester in EtOH (4 mL) is added aqueous 1M NaOH (4 mL) and the mixture is stirred at room temperature for 2 hours. The solution is acidified to pH 2 with aqueous 1M HCl and is extracted with ethyl acetate. The organic layer is washed with water, brine, dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure to give 4-(2-methyl-benzothiazol-6-yl)-butyric acid. MS 236.3 (M+1).
後処理
- extractionis extracted with ethyl acetate
- washThe organic layer is washed with water, brine
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customThe solvent is removed under reduced pressure
出典と根拠
- ORDレコード
- ord-eb87785d7c704ddc9ed50df24a79cd3b
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006249B2
反応ノート
読み込み中…