Hydrochloric Acid → Pyrimidine-2,4-dicarboxylic acid

HRID 1469673ノート

反応式

HRID 1469673 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([O:9]CC)=[O:8])=[N:3][C:2]=1[C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[N:3][C:2]=1[C:12]([OH:14])=[O:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66701935Diethyl pyrimidine-2,4-dicarboxylate

生成物 1

HCID 45117348Pyrimidine-2,4-dicarboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Next, to a stirred solution of diethyl pyrimidine-2,4-dicarboxylate (130 mg, 0.58 mmol) in MeOH (3 mL) is added 1N NaOH (2 mL) and the mixture is stirred at room temperature for 3 hours. The solution is carefully acidified with 1N HCl and the solvent is removed under reduced pressure to give pyrimidine-2,4-dicarboxylic acid. This is used as is in subsequent reactions.

後処理

  1. customthe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-2c586ccd6bde4ebaaf501106ecffc963
出典データセット
uspto-grants-2015_04
特許番号
US09006249B2

反応ノート

読み込み中…