Ammonium Chloride → 1-(3-(Trifluoromethyl)phenoxy)isoquinolin-5-amine

HRID 1469723ノート

反応式

HRID 1469723 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[C:9]2[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)([O-])=O.[NH4+].[Cl-]>CCO.O.[Fe]>[F:24][C:21]([F:22])([F:23])[C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][C:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([NH2:1])[C:5]=2[CH:6]=[CH:7][N:8]=1

参加物

6

反応物 2

HCID 25517Ammonium ChlorideHCID 866922295-Nitro-1-(3-(trifluoromethyl)phenoxy)isoquinoline

生成物 1

HCID 716780491-(3-(Trifluoromethyl)phenoxy)isoquinolin-5-amine収率 94.7%

試薬・触媒・溶媒 3

HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

The title compound was prepared following the procedure described in Step 3 of Intermediate-1 using 5-nitro-1-(3-(trifluoromethyl)phenoxy)isoquinoline (200 mg, 0.59 mmol), iron powder (267 mg, 4.7 mmol), and NH4Cl (312 mg, 5.9 mmol) in EtOH (4 mL) and water (1 mL) to afford 170 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 7.79 (d, J=5.7 Hz, 1H), 7.70-7.50 (m, 6H), 7.40 (t, J=7.8 Hz, 1H), 6.93 (d, J=7.2 Hz, 1H), 6.02 (br s, 2H).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-b1e785c0e1e64a09aa7769bd05caecce
出典データセット
uspto-grants-2015_04
特許番号
US09006257B2

反応ノート

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