Nitric Acid → 5-bromo-7-methyl-8-nitroquinazolin-4(3H)-one
反応式
[Br:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:13])[NH:5][CH:6]=[N:7]2.[N+:14]([O-])([OH:16])=[O:15]>OS(O)(=O)=O>[Br:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]([N+:14]([O-:16])=[O:15])=[C:8]2[C:3]=1[C:4](=[O:13])[NH:5][CH:6]=[N:7]2参加物
4
実験手順
To a solution of 5-bromo-7-methylquinazolin-4(3H)-one (700 mg, 2.94 mmol) in cone. H2SO4 (10 mL) was added fuming HNO3 (185 μL, 2.94 mmol) at 0° C. and then the reaction mixture was stirred at rt for 12 h. Then the reaction mixture was quenched with water and the precipitate obtained was filtered and dried to afford 500 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 12.80 (br s, 1H), 8.40 (s, 1H), 8.24 (s, 1H), 2.41 (s, 3H).
後処理
- customThen the reaction mixture was quenched with water
- customthe precipitate obtained
- filtrationwas filtered
- customdried
出典と根拠
- ORDレコード
- ord-a2efc1c9c79b4a37b1135d8024f063d1
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006257B2
反応ノート
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