Nitric Acid → 5-Fluoro-7-nitroindole-2,3-dione
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].[N+:13]([O-])([OH:15])=[O:14]>OS(O)(=O)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:13]([O-:15])=[O:14])[CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12]参加物
4
実験手順
To a solution of 5-fluoro-1H-indole-2,3-dione (2.5 g, 15.0 mmol) in conc. H2SO4 (9 mL) was added very slowly fuming nitric acid (1.5 mL) at −5 to 0° C. The reaction mixture was stirred at the same temperature for one hour. After completion of the reaction, the reaction mixture was poured onto crushed ice and the resulting precipitate was filtered, washed with water (2-3 times) and dried under vacuum to obtain the title compound as yellow solid (3 g, 94.30%) which was used for the next step directly.
後処理
- customAfter completion of the reaction
- additionthe reaction mixture was poured
- customonto crushed ice
- filtrationthe resulting precipitate was filtered
- washwashed with water (2-3 times)
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-c62581fc360a4378a3109ff931816cfe
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006454B2
反応ノート
読み込み中…