Hydrochloric Acid → Benzoic acid, 2-amino-5-fluoro-3-nitro- (9CI)
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[NH:7]C(=O)[C:5]2=[O:15].[OH:16]O.Cl>[OH-].[Na+]>[NH2:7][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:2]([F:1])=[CH:3][C:4]=1[C:5]([OH:15])=[O:16]参加物
5
実験手順
To a slurry of 5-fluoro-7-nitro-1H-indole-2,3-dione (3 g, 14.2 mmol) in aqueous 5N NaOH solution (30 mL) was added slowly an aq. solution of 33% hydrogen peroxide (3 mL) at 0° C. After completion of the addition, the reaction mixture was stirred at room temperature for 4 h. After completion of the reaction, the reaction mixture was acidified with 2N HCl and the resulting precipitate was filtered, washed with water (2-3 times) and dried under vacuum to obtain the title compound as yellow solid (2 g, 70.17%).
後処理
- additionAfter completion of the addition
- customAfter completion of the reaction
- filtrationthe resulting precipitate was filtered
- washwashed with water (2-3 times)
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-de4a65c515fa47d1830b9e947c4ae8d3
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006454B2
反応ノート
読み込み中…