Hydrochloric Acid → 2-Amino-5-chloro-3-nitrobenzoic acid

HRID 1470621

反応式

HRID 1470621 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[NH:7]C(=O)[C:5]2=[O:15].[OH:16]O.Cl>[OH-].[Na+]>[NH2:7][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:2]([Cl:1])=[CH:3][C:4]=1[C:5]([OH:15])=[O:16]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 149531845-chloro-7-nitro-1H-indole-2,3-dione

生成物 1

HCID 2320552-Amino-5-chloro-3-nitrobenzoic acid収率 70.17%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To a slurry of 5-chloro-7-nitro-1H-indole-2,3-dione (3.2 g, 14.15 mmol) in aqueous 5N NaOH solution (30 mL) added an aq. solution of 33% hydrogen peroxide solution (3 mL) slowly at 0° C. After the addition, the reaction mixture was stirred at room temperature for 4 h. After completion of the reaction, the reaction mixture was acidified with an aq. solution of 2N HCl and the resulting precipitated was filtered, washed with water (2-3 times) and dried under vacuum to obtain the title compound as yellow solid (2 g, 70.17%).

後処理

  1. additionAfter the addition
  2. customAfter completion of the reaction
  3. customthe resulting precipitated
  4. filtrationwas filtered
  5. washwashed with water (2-3 times)
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-17bc456ebff54418a5f6963bfbb23c5b
出典データセット
uspto-grants-2015_04
特許番号
US09006454B2

関連ノート

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