Citric Acid → 2-Amino-3-nitrobenzoic acid
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11]C(=O)[C:9]2=[O:14])([O-:3])=[O:2].OO.C(O)(=O)CC(CC(O)=O)(C(O)=O)[OH:20]>[OH-].[Na+]>[NH2:11][C:12]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=[CH:7][C:8]=1[C:9]([OH:14])=[O:20]参加物
5
実験手順
To a ice cold solution of 7-nitro-1H-indole-2,3-dione (9 g, 47 mmol) in 2 M aqueous sodium hydroxide (50 mL), an aq. solution of 30% hydrogen peroxide (9 mL) was added drop wise. The mixture was warmed to room temperature and stirred overnight. The resulting mixture was carefully acidified by the addition of an aq. saturated citric acid solution. The solid precipitate was collected by filtration, washed with water and dried in a vacuum oven to get 6 g of the required product as a yellow coloured solid (70%).
後処理
- filtrationThe solid precipitate was collected by filtration
- washwashed with water
- customdried in a vacuum oven
出典と根拠
- ORDレコード
- ord-f5f2da426de24df18e2ee56633533e4e
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006454B2
反応ノート
読み込み中…