HCID 68733852、化合物 → HCID 68735663、化合物

反応式

[Si]([O:8][C@@H:9]1[CH2:17][C@@H:12]2[O:13][C:14](=[O:16])[CH2:15][C@@H:11]2[C@H:10]1[CH:18]=[CH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])(C(C)(C)C)(C)C>CO.[Pd]>[OH:8][C@@H:9]1[CH2:17][C@@H:12]2[O:13][C:14](=[O:16])[CH2:15][C@@H:11]2[C@H:10]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

参加物

実験手順

A mixture of 5-2 (595 mg, 1.62 mmol) and 5% Pd/C (556 mg, 0.17 mmol) in methanol (80 mL) was stirred under 1 atm H2 pressure (balloon) overnight. The mixture was then filtered through Celite and the filtrate evaporated. Purification of the residue by flash chromatography on silica gel (Isco Combiflash unit) gave the title compound (396 mg, 96%).

後処理

filtrationThe mixture was then filtered through Celite
customthe filtrate evaporated
customPurification of the residue by flash chromatography on silica gel (Isco Combiflash unit)

出典と根拠

ORDレコード: ord-5fe96b28a459454dac2c226570ba23f7
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09006464B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 68733852HCID 68733852、化合物

生成物 1

HCID 68735663HCID 68735663、化合物収率 96.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒

HCID 887Methanol溶媒

実験手順

後処理

filtrationThe mixture was then filtered through Celite
customthe filtrate evaporated
customPurification of the residue by flash chromatography on silica gel (Isco Combiflash unit)

出典と根拠

ORDレコード: ord-5fe96b28a459454dac2c226570ba23f7
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09006464B2

反応ノート

読み込み中…