Tetrahydrofuran → HCID 67125408、化合物

HRID 1470733

反応式

HRID 1470733 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C@@H](NC(=O)C)C)[CH2:3][CH2:2]1.C([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])C.[F:26][C:27]1[CH:32]=[C:31](F)[CH:30]=[CH:29][N:28]=1.C1C[O:37]CC1>CN(C=O)C>[F:26][C:27]1[CH:32]=[C:31]([N:1]2[CH2:2][CH2:3][CH:4]([C:7]3[CH:8]=[CH:9][C:10]([C@@H:24]([NH:21][C:22](=[O:37])[CH3:23])[CH3:25])=[CH:11][CH:12]=3)[CH2:5][CH2:6]2)[CH:30]=[CH:29][N:28]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 27628382,4-DifluoropyridineHCID 67125510HCID 67125510、化合物

生成物 1

HCID 67125408HCID 67125408、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

To 1.41 g (5.74 mmol) (S)-N-[1-(piperidin-4-yl-phenyl)-ethyl]-acetamide (V.1) in 10 mL THF and 10 mL DMF is added 0.80 mL (5.74 mmol) triethylamine and 0.60 g (5.21 mmol) 2,4-difluoropyridine. The mixture is stirred for 12 h at 0° C. Subsequently the mixture is concentrated in vacuo and the residue is purified by HPLC (C18 RP Sunfire; water (+0.1% TFA)/MeOH) to yield the desired product.

後処理

  1. concentrationSubsequently the mixture is concentrated in vacuo
  2. customthe residue is purified by HPLC (C18 RP Sunfire; water (+0.1% TFA)/MeOH)

出典と根拠

ORDレコード
ord-9412e83cb8a04cb4b8320fe8a5343f11
出典データセット
uspto-grants-2015_04
特許番号
US09006450B2

関連ノート

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