Methylamine → N-methyl-2-chlorothiazole-4-carboxamide
反応式
[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7](Cl)=[O:8])[N:6]=1.[CH2:10]([N:12](CC)CC)C.CN>ClCCl.C1COCC1>[CH3:10][NH:12][C:7]([C:5]1[N:6]=[C:2]([Cl:1])[S:3][CH:4]=1)=[O:8]参加物
6
実験手順
To 445 mg (2.44 mmol) 2-chloro-thiazole-4-carbonyl chloride in 8.0 mL dichloromethane is added a mixture of 0.38 mL (2.69 mmol) triethylamine and 1.35 mL (2.69 mmol) 2 molars solution of methylamine in THF. The mixture is stirred over night, concentrated and the residue is treated with water and NaHCO3 solution. After extraction with ethylacetate the organic phases are combined, dried (Na2SO4) and concentrated to yield the desired product
後処理
- concentrationconcentrated
- additionthe residue is treated with water and NaHCO3 solution
- extractionAfter extraction with ethylacetate the organic phases
- dry with materialdried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c3330bf45f2045e28397d1296808a72a
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09006450B2
反応ノート
読み込み中…