Cesium fluoride → 4-(4,4'-Dichlorobiphenyl-3-yl)-2,2,6,6-tetramethylpyran-3,5-dione

HRID 1470879ノート

反応式

HRID 1470879 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:20])=[C:6]([CH:8]2[C:13](=[O:14])[C:12]([CH3:16])([CH3:15])[O:11][C:10]([CH3:18])([CH3:17])[C:9]2=[O:19])[CH:7]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1.[F-].[Cs+]>COCCOC>[Cl:20][C:5]1[CH:4]=[CH:3][C:2]([C:25]2[CH:26]=[CH:27][C:22]([Cl:21])=[CH:23][CH:24]=2)=[CH:7][C:6]=1[CH:8]1[C:13](=[O:14])[C:12]([CH3:16])([CH3:15])[O:11][C:10]([CH3:18])([CH3:17])[C:9]1=[O:19]

参加物

5

反応物 3

HCID 25953Cesium fluorideHCID 742994-Chlorophenylboronic acidHCID 684878854-(5-Bromo-2-chlorophenyl)-2,2,6,6-tetramethylpyran-3,5-dione

生成物 1

HCID 684882904-(4,4'-Dichlorobiphenyl-3-yl)-2,2,6,6-tetramethylpyran-3,5-dione収率 34.1%

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

反応条件

温度
80 °C

実験手順

A mixture of 4-(5-bromo-2-chlorophenyl)-2,2,6,6-tetramethylpyran-3,5-dione (0.22 g, 0.6 mmol), 4-chlorophenylboronic acid (0.14 g, 0.9 mmol), and cesium fluoride (0.28 g, 1.8 mmol) are stirred together in 1,2-dimethoxyethane (2.4 ml) under an atmosphere of nitrogen at room temperature for 45 minutes. [1,1′-bis(diphenyl-phosphino)ferrocene]dichloropalladium(II) (80 mg, 0.098 mmol) is added and the reaction mixture is heated at 80° C. overnight. The reaction mixture is filtered through diatomaceous earth, washing the filter cake with dichloromethane (7 ml) and water (3 ml). The mixture is acidified to pH1 by addition of 2M aqueous hydrochloric acid, and the organic phase is separated. The aqueous phase is extracted with dichloromethane, and all organic extracts are combined, dried over anhydrous magnesium sulfate, filtered and the filtrate evaporated. The residue is dissolved in N,N-dimethylformamide (approximately 1 ml) and purified by preparative reverse phase HPLC to give 4-(4,4′-dichlorobiphenyl-3-yl)-2,2,6,6-tetramethylpyran-3,5-dione (80 mg).

後処理

  1. filtrationThe reaction mixture is filtered through diatomaceous earth
  2. washwashing the filter cake with dichloromethane (7 ml) and water (3 ml)
  3. additionThe mixture is acidified to pH1 by addition of 2M aqueous hydrochloric acid
  4. customthe organic phase is separated
  5. extractionThe aqueous phase is extracted with dichloromethane
  6. dry with materialdried over anhydrous magnesium sulfate
  7. filtrationfiltered
  8. customthe filtrate evaporated
  9. dissolutionThe residue is dissolved in N,N-dimethylformamide (approximately 1 ml)
  10. custompurified by preparative reverse phase HPLC

出典と根拠

ORDレコード
ord-a0d19497507a4a598259cf874238137a
出典データセット
uspto-grants-2015_04
特許番号
US09006429B2

反応ノート

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