Thionyl Chloride → methyl 3-(3-(3-(chloromethyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate hydrochloride
反応式
O[CH2:2][C:3]1[C:4]([C:9]2[CH:13]=[CH:12][N:11]([CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[N:10]=2)=[N:5][CH:6]=[CH:7][CH:8]=1.O=S(Cl)[Cl:22]>C(Cl)Cl>[ClH:22].[Cl:22][CH2:2][C:3]1[C:4]([C:9]2[CH:13]=[CH:12][N:11]([CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[N:10]=2)=[N:5][CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
To methyl 3-(3-(3-(hydroxymethyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate (51 mg, 0.20 mmol) in DCM (5 mL) was added SOCl2 (1.0 mL) at rt. The reaction mixture was stirred at rt for 4 h and concentrated to dryness. The crude solid was suspended in toluene and concentrated to dryness. The process was repeated three times and dried under vacuum to give methyl 3-(3-(3-(chloromethyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate hydrochloride (63 mg) as an off-white solid, which was used for next step without further purification.