Hydrochloric Acid → Benzoic acid, 3-[(2-methoxyethyl)methylamino]-4-(4-methyl-1-piperazinyl)-

反応式

C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[C:6]([N:17]([CH2:19][CH2:20][O:21][CH3:22])[CH3:18])[CH:5]=1.[OH-].[Na+].Cl>CO>[CH3:22][O:21][CH2:20][CH2:19][N:17]([CH3:18])[C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[N:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]1)[C:3]([OH:23])=[O:2]

参加物

実験手順

To a solution of 150 mg (0.47 mmol) of 3-[(2-methoxy-ethyl)-methyl-amino]-4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester in 5 mL of methanol were added 0.9 mL (0.93 mmol, 2 eq.) of 1N NaOH solution and the reaction mixture left standing overnight at room temperature. The solution was then added with 0.47 mL of 2N hydrochloric acid, the solvent evaporated, and the residue dried at 70° C. under vacuum. The compound was used as such in the subsequent step.