Tetrahydrofuran → HCID 14738110、化合物

HRID 1472233ノート

反応式

HRID 1472233 の反応式
O1CCCC1.[CH3:6][C:7]([CH3:13])([CH:11]=[CH2:12])[CH2:8][CH2:9][OH:10].C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>O>[CH3:6][C:7]([CH3:13])([CH:11]=[CH2:12])[CH2:8][CH2:9][O:10][S:22]([CH3:21])(=[O:24])=[O:23]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 125790984-Penten-1-ol, 3,3-dimethyl-

生成物 1

HCID 14738110HCID 14738110、化合物収率 94%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a tetrahydrofuran (30 ml) solution of 3,3-dimethyl-4-penten-1-ol (3.6 g), triethylamine (4.1 g) and methanesulfonyl chloride (4.3 g) were added at 0° C., followed by raising the temperature to room temperature and further stirring for 30 minutes. Water was added thereto and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline solution, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure to obtain a crude product (5.7 g) of methanesulfonic acid 3,3-dimethyl-4-pentenyl ester. This crude product was subjected to a subsequent reaction without being purified.

後処理

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated saline solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-117e12157de34d1da4edde71378d2972
出典データセット
uspto-grants-2015_04
特許番号
US09012493B2

反応ノート

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