化工社化工社 化学情報印刷レポート · 研究参考用
4-(Dihydroxyboranyl)-3-fluorobenzoic acid → 4-(3-Chloro-6-methoxy-2-quinolinyl)-3-fluorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Dihydroxyboranyl)-3-fluorobenzoic acid | HCID 23134177 | — |
| 反応物 | 2,3-Dichloro-6-methoxyquinoline | HCID 39733293 | — |
| 生成物 | 4-(3-Chloro-6-methoxy-2-quinolinyl)-3-fluorobenzoic acid | HCID 66980029 | — |
反応手順
Scheme 3: starting from 2,3-dichloro-6-methoxyquinoline (Intermediate 4) and 4-borono-3-fluorobenzoic acid. An aqueous/EtOAc workup was performed followed by purification by silica gel column (PE/EtOAc=1/1) to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09012646B2 |
| 出典データセット | uspto-grants-2015_04 |
| ORD ID | ord-3554f2711fac4950a9bd54dbb0221436 |
| 出典メモ | uspto-grants-2015_04 |