Potassium Iodide → (R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol

HRID 1472827

反応式

HRID 1472827 の反応式
[NH2:1][C@H:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][OH:4].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:18][CH2:19][CH2:20][CH2:21]Br.[I-].[K+]>CC(O)C>[C:5]1([C@@H:2]([N:1]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:3][OH:4])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 2724025(R)-beta-aminophenethyl alcohol

生成物 1

HCID 11030628(R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a solution of (R)-2-amino-2-phenyl-ethanol (0.5 g, 3.64 mmol) in 2-propanol (40 mL) were added sodium carbonate (1 g, 9.48 mmol), 1,4-dibromobutane (0.57 mL, 4.74 mmol) and potassium iodide (catalytic) in succession, and the mixture was refluxed overnight. After filtration, the solvent was removed under reduced pressure and the crude was used without further purification (0.53 g, 76%). LCMS method: 2, RT: 2.27 min; MI: 191-193 [M+1].

後処理

  1. temperaturethe mixture was refluxed overnight
  2. filtrationAfter filtration
  3. customthe solvent was removed under reduced pressure
  4. customthe crude was used without further purification (0.53 g, 76%)

出典と根拠

ORDレコード
ord-da06d73d72ff407486fff7064a858cd0
出典データセット
uspto-grants-2015_04
特許番号
US09012633B2

関連ノート

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