Cysteamine → Ethyl thiomorpholine-3-carboxylate
反応式
[NH2:1][CH2:2][CH2:3][SH:4].C(N(CC)CC)C.Br[CH:13]([CH2:19]Br)[C:14]([O:16][CH2:17][CH3:18])=[O:15].C(Cl)(Cl)Cl.C1(C)C=CC=CC=1>C(Cl)(Cl)Cl>[NH:1]1[CH2:2][CH2:3][S:4][CH2:19][CH:13]1[C:14]([O:16][CH2:17][CH3:18])=[O:15]参加物
6
実験手順
A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-di-bromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.
後処理
- filtrationfiltered
- concentrationconcentrated in vacuo
- customto obtain an orange liquid
- distillationdistilled
出典と根拠
- ORDレコード
- ord-0ea27041f7c3480cb095d9b064085a09
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726126
反応ノート
読み込み中…