Sodium Hydroxide → Sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate

HRID 1473302ノート

反応式

HRID 1473302 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH:10]=[CH:11][C:12]([S:18]([O:21]CC(F)(F)F)(=[O:20])=[O:19])=[CH:13]3)=[C:4]([O:27][CH3:28])[CH:3]=1.[OH-].[Na+:30]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH:10]=[CH:11][C:12]([S:18]([O-:21])(=[O:19])=[O:20])=[CH:13]3)=[C:4]([O:27][CH3:28])[CH:3]=1.[Na+:30]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 866873582,2,2-Trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate

生成物 1

HCID 86687359Sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate収率 99.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A round bottomed flask was charged with 2,2,2-trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.729 g, 4.01 mmol) and CH2Cl2 (8.03 mL). Sodium hydroxide (2M in MeOH) (4.01 mL, 8.03 mmol) was added at rt. The solution was capped and maintained at rt for 18 h resulting in a white precipitate. The white solid was collected by vacuum filtration, rinsing with diethyl ether to yield sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.481 g, 3.99 mmol) as a fluffy white solid. The solid was used directly without further purification.

後処理

  1. customThe solution was capped
  2. customresulting in a white precipitate
  3. filtrationThe white solid was collected by vacuum filtration
  4. washrinsing with diethyl ether

出典と根拠

ORDレコード
ord-d91bc7b42bd946f3b2675a89d9ce6d67
出典データセット
uspto-grants-2015_04
特許番号
US09012443B2

反応ノート

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