Trifluoroacetic acid → HCID 86678431、化合物

HRID 1473718ノート

反応式

HRID 1473718 の反応式
C(OC([NH:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([OH:22])=[O:21])[C:10]([O:12]C(C)(C)C)=[O:11])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([O-:22])=[O:21])[C:10]([OH:12])=[O:11].[NH4+:8]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86678430HCID 86678430、化合物

生成物 1

HCID 86678431HCID 86678431、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-tert-Butyl 6-hydrogen (2S)-2-[(tert-butoxycarbonyl)amino]-5-(3-fluoropropyl)-hexanedioate (57.0 mg, 0.15 mmol) and trifluoroacetic acid (0.5 mL) and dichloromethane (0.5 mL) was stirred at r.t. for 30 min. Then the mixture was concentrated under reduced pressure and the residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min).

後処理

  1. concentrationThen the mixture was concentrated under reduced pressure
  2. customthe residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min)

出典と根拠

ORDレコード
ord-ff2856ec28f247b1be4d2534fe0048a4
出典データセット
uspto-grants-2015_04
特許番号
US09017645B2

反応ノート

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