Thionyl Chloride → 8-(Chloromethyl)imidazo[1,2-a]pyridine
反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10]O)[C:5]=12.S(Cl)([Cl:14])=O>>[Cl:14][CH2:10][C:6]1[C:5]2[N:4]([CH:3]=[CH:2][N:1]=2)[CH:9]=[CH:8][CH:7]=1参加物
3
反応条件
- 温度
- 75 °C
実験手順
A mixture of imidazo[1,2-a]pyridin-8-ylmethanol (800 mg) and excess thionyl chloride was stirred at 70-80° C. for 8 h. Excess thionyl chloride was removed under vacuum. The residue was then diluted with toluene and evaporated. This procedure was repeated 3 times.
後処理
- customExcess thionyl chloride was removed under vacuum
- additionThe residue was then diluted with toluene
- customevaporated
出典と根拠
- ORDレコード
- ord-76526a3247e240ae85b244aac7857c6b
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09018210B2
反応ノート
読み込み中…