反応式
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH2:7][C:8]1[CH:9]=[C:10](C)[CH:11]=[C:12]([OH:14])[CH:13]=1.Cl.[CH3:17]CO>>[CH3:17][C:11]1[CH:10]=[CH:9][C:8]([NH:7][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)=[CH:13][C:12]=1[OH:14]参加物
5
反応条件
- 温度
- 90 °C
実験手順
Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.27 mL, 3.05 mmol), 5-amino-3-methylphenol (188 mg, 1.5 mmol) and 37% HCl solution (0.26 mL, 3.05 mmol) in 10% aqueous EtOH solution (5 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 74% yield (233 mg).
出典と根拠
- ORDレコード
- ord-349dc3502ff949eb9b00a037f64d2998
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09018209B2
関連ノート
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