3-Bromo-2,5-dimethylbenzoic acid → (3-bromo-2,5-dimethylphenyl)methanol

HRID 1474322ノート

反応式

HRID 1474322 の反応式
[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([CH3:11])[CH:10]=1

参加物

3

反応物 1

HCID 592382453-Bromo-2,5-dimethylbenzoic acid

生成物 1

HCID 10656303(3-bromo-2,5-dimethylphenyl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-bromo-2,5-dimethylbenzoic acid (3.5 g, 15 mmol) in anhydrous THF was added borane THF complex (1.0 M, 25 mL, 25 mmol) at 0, then the reaction was warmed to ambient temperature overnight. The reaction was quenched with MeOH and concentrated to afford (3-bromo-2,5-dimethylphenyl)methanol.

後処理

  1. customThe reaction was quenched with MeOH
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-7493043f55034c139b232a4efd223ef5
出典データセット
uspto-grants-2015_04
特許番号
US09018211B2

反応ノート

読み込み中…