Methyl iodide → Methyl 2-(3-bromo-2-methoxyphenyl)acetate

HRID 1474395ノート

反応式

HRID 1474395 の反応式
[Br:1][C:2]1[C:3]([OH:13])=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1.[C:14]([O-])([O-])=O.[K+].[K+].CI>CN(C=O)C.CCOC(C)=O.O>[Br:1][C:2]1[C:3]([O:13][CH3:14])=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 12159074Methyl 2-(3-bromo-2-hydroxyphenyl)acetate

生成物 1

HCID 66643982Methyl 2-(3-bromo-2-methoxyphenyl)acetate

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
50 °C

実験手順

To a solution of methyl (3-bromo-2-hydroxyphenyl)acetate (18.7 g, 76.3 mmol) in 200 mL of DMF was added K2CO3 (52.7 g, 382 mmol), MeI (14.0 mL, 229 mmol). The mixture was stirred at 50° C. for 3 hours. The reaction solution was diluted with EtOAc and water. The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was purified column chromatography to give methyl [3-bromo-2-(methyloxy)phenyl]acetate.

後処理

  1. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  2. concentrationconcentrated
  3. customThe residue was purified column chromatography

出典と根拠

ORDレコード
ord-fd16f6d6d6aa49649910aed9d0c7800a
出典データセット
uspto-grants-2015_04
特許番号
US09018211B2

反応ノート

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