2-(4-(benzyloxy)-2-methylphenyl)-N,N-dimethylacetamide → 2-(4-hydroxy-2-methylphenyl)-N,N-dimethylacetamide

HRID 1474670ノート

反応式

HRID 1474670 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])=[C:11]([CH3:21])[CH:10]=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([N:18]([CH3:19])[CH3:20])=[O:17])=[C:11]([CH3:21])[CH:10]=1

参加物

4

反応物 1

HCID 708189752-(4-(benzyloxy)-2-methylphenyl)-N,N-dimethylacetamide

生成物 1

HCID 867111812-(4-hydroxy-2-methylphenyl)-N,N-dimethylacetamide

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

2-[4-(benzyloxy)-2-methylphenyl]-N,N-dimethylacetamide (680 mg, 2.40 mmol) was dissolved in ethanol (4 ml) and palladium hydroxide on carbon (20%) (169 mg, 0.240 mmol) added. The mixture was stirred under an atmosphere of hydrogen gas at RT overnight. The mixture was filtered and the filtrate concentrated under reduced pressure to afford the title compound. LC/MS (m/z): 194 (M+H)+.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e7ac5d08006a4faea82a24a549138e04
出典データセット
uspto-grants-2015_04
特許番号
US09018224B2

反応ノート

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