Trifluoroacetic acid → (4-{2-[(1S,2R)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethoxy}-2,5-difluorophenyl)acetic acid
反応式
C(O[C:6]1([F:38])[C:33](CC=O)=[CH:32][C:31]([F:37])=[CH:30][CH:7]1[O:8][CH2:9][CH2:10][C@@H:11]1[CH2:13][C@@H:12]1[CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:16][CH2:15]1)(C)(C)C.[C:39]([OH:45])([C:41](F)(F)F)=[O:40]>ClCCl>[CH2:23]([O:22][C:20]([N:17]1[CH2:16][CH2:15][CH:14]([C@H:12]2[CH2:13][C@H:11]2[CH2:10][CH2:9][O:8][C:7]2[C:6]([F:38])=[CH:33][C:32]([CH2:41][C:39]([OH:45])=[O:40])=[C:31]([F:37])[CH:30]=2)[CH2:19][CH2:18]1)=[O:21])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
Benzyl 4-{(1R,2S)-2-[2-(2-tert-butoxy-2-oxoethyl-2,5-difluorophenoxy)ethyl]cyclopropyl}piperidine-1-carboxylate (0.350 g, 0.661 ml) was dissolved in dichloromethane (1.5 ml) and TFA (1.5 ml) added. The mixture was stirred at RT for 3.5 h and the volatiles removed under vacuum to afford the title compound. LC/MS (m/z): 474.3 (M+H)+.