Triethylamine → HCID 86711893、化合物

反応式

[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[N:9][C:8]([C:12](OCC)=[O:13])=[N:7]1.O.[NH2:21][NH2:22].CCN(CC)CC>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[N:9][C:8]([C:12]([NH:21][NH2:22])=[O:13])=[N:7]1

参加物

実験手順

To a solution of ethyl 1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazole-3-carboxylate (1.28 g, 3.92 mmol) in MeOH (19 mL) was added hydrazine hydrate (784 μL, 7.84 mmol) and NEt3 (2.47 mL, 17.6 mmol). The reaction was allowed to stir overnight at RT. The solvent was then removed under reduced pressure and the crude material was spun down from toluene (3×) to give a white solid, which was used directly for the next step without further purification. MS (ES+) C11H12BrN5O requires: 309, 311 found: 310, 312 [M+H]+(1:1).