HCID 86672573、化合物 → 4-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl Ester

HRID 1475803ノート

反応式

HRID 1475803 の反応式
[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:5]=1

参加物

5

反応物 2

HCID 86672573HCID 86672573、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 671694814-(2-Methanesulfonyl-ethyl)-3-(2-m-tolyl-ethoxy)-benzoic Acid Methyl Ester収率 99.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

250 mg of 4-((E)-2-Methanesulfonyl-vinyl)-3-(2-m-tolyl-ethoxy)-benzoic acid methyl ester were dissolved using 10 ml of methanol and hydrogenated under an 1.5 bar atmosphere of hydrogen using 50 mg of Pd/C (10%, 50% water) for 30 minutes. The catalyst was then removed by filtration and the solution evaporated to yield 250 mg of the title compound that was used without further purification.

後処理

  1. customThe catalyst was then removed by filtration
  2. customthe solution evaporated

出典と根拠

ORDレコード
ord-d5e6544ed1e84e8e93f870acd9b345e3
出典データセット
uspto-grants-2015_04
特許番号
US09018383B2

反応ノート

読み込み中…