1,2-Dihydroquinoline → Hydrocarbostyril

反応式

N1C2C(=CC=CC=2)C=CC1.[O:11]=[C:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]1C(OC(C)(C)C)=O>>[NH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:20][CH2:21][C:12]1=[O:11]

参加物

反応物 2

HCID 52314021,2-Dihydroquinoline

HCID 10538446N-Boc-3,4-dihydro-2(1H)-quinolinone

生成物 1

HCID 64796Hydrocarbostyril

実験手順

A dihydroquinoline compound (ai1) having a tert-butoxycarbonyl group (Boc group) (i.e., tert-butyl 2-oxo-3,4-dihydroquinoline-1(2H)-carboxylate) was produced from 3,4-dihydroquinolin-2(1H)-one (raw material (aa)) by the following method (see scheme (1-1)).

出典と根拠

ORDレコード: ord-b71181b4d57e465f8c6c45547172b9ce
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09018394B2

反応ノート

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