Trifluoroacetic acid → HCID 67257638、化合物
反応式
[O:1]=[C:2]1[N:7]([CH2:8][C:9]2[O:13][N:12]=[C:11]([CH2:14][O:15][CH2:16][CH2:17][CH3:18])[N:10]=2)[C:6]2[CH:19]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[S:21][C:5]=2[C:4](=[O:28])[N:3]1[CH:29]1[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30]1.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>C(Cl)Cl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[C:22]1([C:20]2[S:21][C:5]3[C:4](=[O:28])[N:3]([CH:29]4[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]4)[C:2](=[O:1])[N:7]([CH2:8][C:9]4[O:13][N:12]=[C:11]([CH2:14][O:15][CH2:16][CH2:17][CH3:18])[N:10]=4)[C:6]=3[CH:19]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1参加物
4
実験手順
To a solution of tert-butyl 4-[2,4-dioxo-6-phenyl-1-{[3-(propoxymethyl)-1,2,4-oxadiazol-5-yl]methyl]-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (500 mg, compound B69) in DCM (10 ml) is added trifluoroacetic acid (10 ml). After 1 h at RT all volatile materials are removed in vacuo. The residue is taken up in diethyl ether, the resulting precipitate is filtered off, washed with diethyl ether and dried in vacuo to afford the title compound as a solid.