Methanol → Methyl 8-fluoro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

反応式

[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:10](=[O:12])[NH:9][C:8]([C:13]([OH:15])=[O:14])=[CH:7]2.O=S(Cl)Cl.[CH3:20]O>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:10](=[O:12])[NH:9][C:8]([C:13]([O:15][CH3:20])=[O:14])=[CH:7]2

参加物

反応物 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 903871878-Fluoro-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid

生成物 1

HCID 90387081Methyl 8-fluoro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate収率 80%

実験手順

To a solution of 8-fluoro-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid (4 g, 19.3 mmol) in MeOH (100 mL) was added SOCl2 (20 mL) at 0° C. The reaction mixture was stirred at RT for 30 minutes and then heated to reflux for 5 hours. The reaction mixture was subsequently concentrated in vacuo. The crude product was purified by column chromatography eluting with petroleum ether and ethyl acetate (PE/EtOAc=1:1-1:2 gradient) to give a second batch of the title compound (3 g, 80%). 1H NMR (400 MHz, DMSO-d6) δ ppm 11.19 (s, 1H), 7.79-7.71 (m, 2H), 7.42-7.38 (m, 2H), 3.89 (s, 3H).