Sodium periodate → HCID 59627525、化合物

HRID 1477316ノート

反応式

HRID 1477316 の反応式
[OH:1][C:2]1(CO)[CH2:7][O:6][C@H:5]([C:8]2[CH:13]=[C:12]([F:14])[C:11]([F:15])=[CH:10][C:9]=2[F:16])[C@@H:4]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:3]1.I([O-])(=O)(=O)=O.[Na+]>O1CCCC1.O>[O:1]=[C:2]1[CH2:7][O:6][C@H:5]([C:8]2[CH:13]=[C:12]([F:14])[C:11]([F:15])=[CH:10][C:9]=2[F:16])[C@@H:4]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[CH2:3]1

参加物

5

反応物 2

HCID 23667635Sodium periodateHCID 86615516HCID 86615516、化合物

生成物 1

HCID 59627525HCID 59627525、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of tert-butyl [(2R,3S)-5-hydroxy-5-(hydroxymethyl)-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate (223 mg, 0.59 mmol) in tetrahydrofuran (4 mL) was added a solution of sodium periodate (143 mg, 0.67 mmol) in water (1.3 mL) and the mixture stirred for 3 hours. The mixture was concentrated and purified by flash chromatography (silica, gradient 5-20% ethyl acetate in chloroform) to yield tert-butyl [(2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate as white solid.

後処理

  1. concentrationThe mixture was concentrated
  2. custompurified by flash chromatography (silica, gradient 5-20% ethyl acetate in chloroform)

出典と根拠

ORDレコード
ord-b1b13b4a6dad4259aee62633197a5497
出典データセット
uspto-grants-2016_08
特許番号
US09403790B2

反応ノート

読み込み中…