HCID 86688408、化合物 → HCID 86688407、化合物
反応式
[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13]C(=O)C2C=CC=CC=2)=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>[OH-].[Na+]>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH2:13])=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:2])[CH3:3]参加物
3
反応条件
- 温度
- 90 °C
実験手順
A suspension of compound 24 (5 g, 15.1 mmol) in 30 mL of 5% NaOH aqueous solution was stirred in an oil bath of 90° C. for 8 hrs and cooled down to room temperature. Ice was added while stirring to the reaction mixture. The resulting suspension was filtered, and the cake was washed with cold water (10 mL×3) and further dried in vacuo to afford the desired product 8 as an off-white powder.
後処理
- temperaturecooled down to room temperature
- additionIce was added
- stirringwhile stirring to the reaction mixture
- filtrationThe resulting suspension was filtered
- washthe cake was washed with cold water (10 mL×3)
- customfurther dried in vacuo
出典と根拠
- ORDレコード
- ord-5d1cc4a3486b489aabbd729ff583c6fd
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09403815B2
反応ノート
読み込み中…