HCID 86705039、化合物 → 6-Fluoro-1H-indol-4-amine

HRID 1477840ノート

反応式

HRID 1477840 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+]([O-])=O)[C:5]([CH:11]=[CH:12][N:13](C)C)=[C:4]([N+:16]([O-])=O)[CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]2[CH:11]=[CH:12][NH:13][C:6]=2[CH:7]=1

参加物

4

反応物 1

HCID 86705039HCID 86705039、化合物

生成物 1

HCID 247280226-Fluoro-1H-indol-4-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

2-(4-fluoro-2,6-dinitrophenyl)-N,N-dimethylethenamine (18 g, 0.071 mol) was dissolved in ethanol (1000 mL), and charged with 10% palladium on carbon (2.0 g). The mixture was hydrogenated at room temperature overnight. The mixture was filtrated through celite and washed with ethanol. The filtrate was combined and evaporated in vacuo. The residue was purified by silica gel flash chromatography (PE: EA=2:1) to afford the title compound. LC/MS m/z=151.2 [M+H]+.

後処理

  1. filtrationThe mixture was filtrated through celite
  2. washwashed with ethanol
  3. customevaporated in vacuo
  4. customThe residue was purified by silica gel flash chromatography (PE: EA=2:1)

出典と根拠

ORDレコード
ord-d20c72390c04403f87606094a2851b4e
出典データセット
uspto-grants-2016_08
特許番号
US09403807B2

反応ノート

読み込み中…