Tyramine → 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol
反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([O:17][CH3:18])[O:15][CH3:16])[CH:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1>>[CH3:16][O:15][CH:14]([O:17][CH3:18])[C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=3)[N:7]=2)[CH:13]=[CH:12][CH:11]=1参加物
3
実験手順
Intermediate 26 was coupled with tyramine following procedure F. The product was purified by flash chromatography using 99:1 CH2Cl2:MeOH as eluent. Yield: 35%. LC-MS showed the product had the expected M+H+ of 366.
後処理
- customThe product was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-571c36ad8b334d5587622f912b5c2a15
- 出典データセット
- uspto-grants-2010_06