Hydrochloric Acid → 3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde

HRID 14785

反応式

HRID 14785 の反応式
C[O:2][CH:3](OC)[C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=3)[N:11]=2)[CH:7]=[CH:8][CH:9]=1.Cl>CC#N>[OH:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:18][CH2:17][NH:16][C:12]2[N:11]=[C:10]([C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[CH:3]=[O:2])[CH:15]=[CH:14][N:13]=2)=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 670450574-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol

生成物 1

HCID 866032623-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Intermediate 27 (2.2 g) was treated with 30 mL of 3N HCl in 60 mL of CH3CN at room temperature overnight. The solvent was removed by rotary evaporation and the residue partitioned between ethyl acetate/sat. NaHCO3. Yield: 1.9 g, 99%. LC-MS showed the product had the expected M+H+ of 320.

後処理

  1. customThe solvent was removed by rotary evaporation
  2. customthe residue partitioned between ethyl acetate/

出典と根拠

ORDレコード
ord-35af2987e5d84ed19c3e51c6c0d54461
出典データセット
uspto-grants-2010_06
特許番号
US07732444B2

関連ノート

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