(S)-Tert-butyl 3-(azidomethyl)piperidine-1-carboxylate → tert-Butyl (3R)-3-(aminomethyl)piperidine-1-carboxylate
反応式
[N:1]([CH2:4][C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][C@H:5]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1参加物
4
実験手順
(S)-tert-butyl 3-(azidomethyl)piperidine-1-carboxylate (5.38 g, 22.40 mmol) was dissolved in MeOH (50 ml), and then Pd/C (5% mol) was added, followed by stirring at room temperature under H2 (gas) for 9 hours. After the completion of the reaction, the reaction mixture was filtered through celite, followed by filtration and concentration under reduced pressure, and then the next reaction was advanced without purification.
後処理
- customAfter the completion of the reaction
- filtrationthe reaction mixture was filtered through celite
- filtrationfollowed by filtration and concentration under reduced pressure
- customthe next reaction
- customwas advanced without purification
出典と根拠
- ORDレコード
- ord-f6fc61fefd43412c92d12202819e8678
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09403831B2
反応ノート
読み込み中…